Endocrine Abstracts

The sex hormone 17β-estradiol (E2) exerts its pleiotropic effects through the binding to the ligand-activated transcription factor estrogen receptor alpha (ERa). The E2:ERa complex regulates several physiological processes including cell survival and proliferation through transcriptional (i.e., estrogen responsive element (ERE)-based gene transcription) and non-transcriptional membrane-initiated effects (i.e., activation of signalling cascades).Many...